Mechanism of action of LactoSporin®
According to Riazi et al., 2012, LactoSporin® might exert antimicrobial action by targeting the plasma membrane of sensitive microbial cells and forming transient pores followed by leakage of intracellular contents and dissipation of pH gradient component of proton motive force (PMF). The PMF is important for physiological processes such as ATP generation, ion transport as well as motility, thus affecting the sustenance of the organism.
Results
LactoSporin® was found to be highly active against the important skin pathogens such as Staphylococcus aureus, Streptococcus epidermis, acne-causing bacterium – Propionibacterium acne, as well as against an opportunistic pathogen – Pseudomonas aeurginosa.
The stable and broad-spectrum antimicrobial potentiality of LactoSporin®
It exhibits a broad spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria. The minimum inhibitory concentration (MIC) against various pathogenic groups was found to be in the range of 0.5 to 4.0% v/v. LactoSporin® was effective in killing the tested harmful bacteria at varied pH (2-5) and temperature ranges (70 – 90 °C). Also, LactoSporin® retained the antimicrobial efficacy in varied storage conditions (Stable & Accelerated condition).
Effect of various temperature and pH in the antimicrobial activity of LactoSporin®
Effect of stability conditions on the antimicrobial activity of LactoSporin®
