Hair is one of the fastest growing tissues of the human body. Hair follicles undergo repetitive regenerative cycles consisting of anagen (rapid growth, active stage), catagen (regression, physiological involution stage), and telogen (resting stage). Hair proliferation is controlled by androgen hormones (e.g. testosterone). Androgens shorten the anagen phase by targeting dermal papilla cells (DPCs) of the hair follicle. The 5α-dihydrotestosterone (potent active metabolite generated by 5α-reductase) has greater affinity towards androgen receptors in DPCs. Thus, extending the anagen phase is an effective treatment for the prevention of hair loss.
LactoSporin® capability of hair growth promotion was assessed by estimating the proliferation of Human Follicle Dermal Papilla cells (HFDPC) in vitro.
LactoSporin® induced 29.7% proliferation of dermal papilla cells and 16.2% inhibition of 5α-reductase activity in vitro at 0.5% v/v LactoSporin® concentration.