The surface of the tooth is covered by a biofilm of microorganism, especially bacteria. Tooth decay or dental caries results from the acids secreted by certain bacteria. Streptococcus mutans are the common type of acid-producing oral pathogen that is present mainly in the mouth, pharynx and intestine. It decays the tooth by secreting glucose polysaccharides known as glucans.
LactoSporin® was evaluated for the effect of oral hygiene by assessing its impact on the growth and drop in pH level of S. mutans.
A significant reduction (for about 12 hours) in the growth, rate of pH drop (prevention from detrimental acidic environment) and glucan production was observed in S. mutans within 5 minutes of the LactoSporin® treatment. Thus, suggesting the role of LactoSporin® in oral hygiene.
Inhibition of pH drop
Water insoluble glucan inhibition
Prevention of pH drop and glucan production by LactoSporin®
Biofilm inhibitory potential of LactoSporin®
Biofilm, the extracellular matrix on living or non-living surfaces are less susceptible to antimicrobial agents. Thus, these associations of microbial cells are difficult to target and treat.
Biofilm inhibitory potential of LactoSporin® was evaluated by using an antimicrobial test known as broth micro-dilution method.
LactoSporin® exhibited a concentration-dependent biofilm inhibitory effect against S. mutans, S. aureus, P. aeruginosa and E. Coli.